Oxidative Stress: A Pathogenic Mechanism for Niemann-Pick Type C
Por um escritor misterioso
Last updated 05 outubro 2024
Niemann-Pick type C (NPC) disease is a neurovisceral atypical lipid storage disorder involving the accumulation of cholesterol and other lipids in the late endocytic pathway. The pathogenic mechanism that links the accumulation of intracellular cholesterol with cell death in NPC disease in both the CNS and the liver is currently unknown. Oxidative stress has been observed in the livers and brains of NPC mice and in different NPC cellular models. Moreover, there is evidence of an elevation of oxidative stress markers in the serumof NPC patients. Recent evidence strongly suggests that mitochondrial dysfunction plays an important role in NPC pathogenesis and that mitochondria could be a significant source of oxidative stress in this disease. In this context, the accumulation of vitamin E in the late endosomal/lysosomal compartments in NPC could lead to a potential decrease of its bioavailability and could be another possible cause of oxidative damage. Another possible source of reactive species in NPC is the diminished activity of different antioxidant enzymes. Moreover, because NPC is mainly caused by the accumulation of free cholesterol, oxidized cholesterol derivatives produced by oxidative stress may contribute to the pathogenesis of the disease.
Unbiased yeast screens identify cellular pathways affected in
Niemann–Pick type C disease: cellular pathology and
PDF) The pathogenesis of Niemann-Pick type C disease: A role for
The pathogenesis of Niemann–Pick type C disease: a role for
Biomedicines, Free Full-Text
The pathogenesis of Niemann–Pick type C disease: a role for
PDF] Oxidative Stress: A Pathogenic Mechanism for Niemann-Pick
IJMS, Free Full-Text
A proposed model for the pathogenesis of Niemann-Pick disease type
Elevated CSF levels of A 38 , A 40 , and A 42 in Niemann-Pick type
Investigation of Brain Iron in Niemann-Pick Type C: A 7T
Massive Accumulation of Sphingomyelin Affects the Lysosomal and
IJMS, Free Full-Text
Recomendado para você
-
IJMS, Free Full-Text05 outubro 2024
-
Niemann-Pick Type C Disease Reveals a Link between Lysosomal Cholesterol and PtdIns(4,5)P2 That Regulates Neuronal Excitability - ScienceDirect05 outubro 2024
-
Niemann-Pick Disease - Western New York Urology Associates05 outubro 2024
-
National Niemann-Pick Disease Foundation, Inc. - October is Global05 outubro 2024
-
Niemann Pick disease05 outubro 2024
-
Gene therapy shows promise for treating Niemann-Pick disease type05 outubro 2024
-
Niemann-Pick Disease - Types, Causes, Symptoms, Diagnosis & Treatment05 outubro 2024
-
Critical role for glycosphingolipids in Niemann-Pick disease type05 outubro 2024
-
Niemann-Pick disease type C as a neurovisceral disease. Schematic05 outubro 2024
-
Health Tip on New Treatment that Shows Promise in Niemann-Pick05 outubro 2024
você pode gostar
-
One-Punch Man: 3ª temporada do anime é anunciada05 outubro 2024
-
Como os espaços de trabalho podem impactar na produtividade e criatividade do time? - Studio Universalis05 outubro 2024
-
Desapego Games - Roblox > Melhor script de Roblox + executor - blox Fruits05 outubro 2024
-
SAVEIRO CROSS CABINE-DUPLA, NO USO – Autoentusiastas05 outubro 2024
-
Garry's Mod Dark RP runs great on Deck! Back buttons work nicely for the extra keybinds. : r/SteamDeck05 outubro 2024
-
GTA 6 - FOI CONFIRMADO A DATA DE LANÇAMENTO DO JOGO DA ROCKSTAR05 outubro 2024
-
DVD ANIME TOKYO MEW MEW NEW~♡ VOL.1-12 END ENGLISH SUBTITLE05 outubro 2024
-
AnimeLab Logo PNG vector in SVG, PDF, AI, CDR format05 outubro 2024
-
GTA San Andreas Download Apk Android Mobile Game Full Version Free Download - Hut Mobile05 outubro 2024
-
Cruzeiro x Grêmio: veja as opções para assistir o jogo deste sábado05 outubro 2024