DREAMS: deep read-level error model for sequencing data applied to low-frequency variant calling and circulating tumor DNA detection, Genome Biology
Por um escritor misterioso
Last updated 30 setembro 2024
Circulating tumor DNA detection using next-generation sequencing (NGS) data of plasma DNA is promising for cancer identification and characterization. However, the tumor signal in the blood is often low and difficult to distinguish from errors. We present DREAMS (Deep Read-level Modelling of Sequencing-errors) for estimating error rates of individual read positions. Using DREAMS, we develop statistical methods for variant calling (DREAMS-vc) and cancer detection (DREAMS-cc). For evaluation, we generate deep targeted NGS data of matching tumor and plasma DNA from 85 colorectal cancer patients. The DREAMS approach performs better than state-of-the-art methods for variant calling and cancer detection.
DREAMS: deep read-level error model for sequencing data applied to
Whole genome error-corrected sequencing for sensitive circulating
DREAMS: deep read-level error model for sequencing data applied to
Bioinformatic strategies for the analysis of genomic aberrations
Systematic evaluation of error rates and causes in short samples
Evaluating the performance of low-frequency variant calling tools
Genome-wide cell-free DNA mutational integration enables ultra
The challenge of somatic variant detection accuracy in liquid
Multimodal analysis of cell-free DNA whole-genome sequencing for
PDF) DREAMS: Deep Read-level Error Model for Sequencing data
Machine learning-based genome-wide interrogation of somatic copy
Machine learning guided signal enrichment for ultrasensitive
Analysis of error profiles in deep next-generation sequencing data
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